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Pak4 Induces Premature Senescence via a Pathway Requiring p16(INK4)/p19(ARF) and Mitogen-Activated Protein Kinase Signaling
Exposure of primary cells to mitogenic stimuli or oncogenes often causes them to undergo premature senescence. This is most likely a protective function that prevents uncontrolled proliferation. Pak4 is a target for the Rho GTPase Cdc42. Pak4 is overexpressed in human tumor cell lines, and it is the...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1265798/ https://ncbi.nlm.nih.gov/pubmed/16227603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.21.9532-9542.2005 |
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