Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice.

The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival. Pak4 knockout mice are embryonic lethal, while Pak5, Pak6, and Pak5/Pak6 double knockout mice are viable and f...

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Main Authors: Melody A Furnari, Michelle L Jobes, Tanya Nekrasova, Audrey Minden, George C Wagner
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2013-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC3620390?pdf=render
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