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Optimization of the Cell Wall Microenvironment Allows Increased Production of Recombinant Bacillus anthracis Protective Antigen from B. subtilis

The stability of heterologous proteins secreted by gram-positive bacteria is greatly influenced by the microenvironment on the trans side of the cytoplasmic membrane, and secreted heterologous proteins are susceptible to rapid degradation by host cell proteases. In Bacillus subtilis, degradation occ...

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書誌詳細
出版年:Appl Environ Microbiol
主要な著者: Thwaite, Joanne E., Baillie, Les W. J., Carter, Noel M., Stephenson, Keith, Rees, Mark, Harwood, Colin R., Emmerson, Peter T.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126578/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11772631/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.68.1.227-234.2002
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