Role of Dot1-Dependent Histone H3 Methylation in G(1) and S Phase DNA Damage Checkpoint Functions of Rad9

We screened radiation-sensitive yeast mutants for DNA damage checkpoint defects and identified Dot1, the conserved histone H3 Lys 79 methyltransferase. DOT1 deletion mutants (dot1Δ) are G(1) and intra-S phase checkpoint defective after ionizing radiation but remain competent for G(2)/M arrest. Mutat...

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Detalhes bibliográficos
Main Authors: Wysocki, Robert, Javaheri, Ali, Allard, Stéphane, Sha, Fei, Côté, Jacques, Kron, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Chromosome Structure and Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265753/
https://ncbi.nlm.nih.gov/pubmed/16166626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.19.8430-8443.2005
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