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Role of Dot1-Dependent Histone H3 Methylation in G(1) and S Phase DNA Damage Checkpoint Functions of Rad9
We screened radiation-sensitive yeast mutants for DNA damage checkpoint defects and identified Dot1, the conserved histone H3 Lys 79 methyltransferase. DOT1 deletion mutants (dot1Δ) are G(1) and intra-S phase checkpoint defective after ionizing radiation but remain competent for G(2)/M arrest. Mutat...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1265753/ https://ncbi.nlm.nih.gov/pubmed/16166626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.19.8430-8443.2005 |
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