Cbp Deficiency Alters Csk Localization in Lipid Rafts but Does Not Affect T-Cell Development

The ubiquitously expressed transmembrane adaptor Csk-binding protein (Cbp) recruits Csk to lipid rafts, where the latter exerts its negative regulatory effect on the Src family of protein tyrosine kinases. We have inactivated Cbp in the mouse germ line. In contrast to Csk gene inactivation, which le...

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Detalhes bibliográficos
Main Authors: Xu, Shengli, Huo, Jianxin, Tan, Joy En-Lin, Lam, Kong-Peng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265734/
https://ncbi.nlm.nih.gov/pubmed/16166631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.19.8486-8495.2005
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