Engineering of Primary Carbon Metabolism for Improved Antibiotic Production in Streptomyces lividans

Deletions were made in Streptomyces lividans in either of two genes (zwf1 and zwf2) encoding isozymes of glucose-6-phosphate dehydrogenase, the first enzyme in the oxidative pentose phosphate pathway (PPP). Each mutation reduced the level of Zwf activity to approximately one-half that observed in th...

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Veröffentlicht in:	Appl Environ Microbiol
Hauptverfasser:	Butler, Michael J., Bruheim, Per, Jovetic, Srdjan, Marinelli, Flavia, Postma, Pieter W., Bibb, Mervyn J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Physiology and Biotechnology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126421/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12324314/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.68.10.4731-4739.2002
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