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Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line
The Rac/Rho-specific guanine nucleotide exchange factor, Vav-1, is a key component of the T-cell antigen receptor (TCR)-linked signaling machinery. Here we have used somatic cell gene-targeting technology to generate a Vav-1-deficient Jurkat T-cell line. The J.Vav1 cell line exhibits dramatic defect...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126295/ https://ncbi.nlm.nih.gov/pubmed/12234921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf499 |
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