Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line

The Rac/Rho-specific guanine nucleotide exchange factor, Vav-1, is a key component of the T-cell antigen receptor (TCR)-linked signaling machinery. Here we have used somatic cell gene-targeting technology to generate a Vav-1-deficient Jurkat T-cell line. The J.Vav1 cell line exhibits dramatic defect...

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Bibliografiska uppgifter

I publikationen:	EMBO J
Huvudupphov:	Cao, Youjia, Janssen, Erin M., Duncan, Andrew W., Altman, Amnon, Billadeau, Daniel D., Abraham, Robert T.
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Publishing Group 2002
Ämnen:	Articles
Länkar:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126295/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12234921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf499
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