Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line

The Rac/Rho-specific guanine nucleotide exchange factor, Vav-1, is a key component of the T-cell antigen receptor (TCR)-linked signaling machinery. Here we have used somatic cell gene-targeting technology to generate a Vav-1-deficient Jurkat T-cell line. The J.Vav1 cell line exhibits dramatic defect...

全面介紹

書目詳細資料

發表在:	EMBO J
Principais autores:	Cao, Youjia, Janssen, Erin M., Duncan, Andrew W., Altman, Amnon, Billadeau, Daniel D., Abraham, Robert T.
格式:	Artigo
語言:	Inglês
出版:	Nature Publishing Group 2002
主題:	Articles
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126295/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12234921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf499
標簽:	添加標簽 沒有標簽, 成為第一個標記此記錄!