Mutation of a Single Amino Acid Residue in the Basic Region of the Epstein-Barr Virus (EBV) Lytic Cycle Switch Protein Zta (BZLF1) Prevents Reactivation of EBV from Latency

Zta, the product of the BZLF1 gene carried by Epstein-Barr virus (EBV), is crucial for reactivation of EBV from latency. Zta is a member of the bZIP family of transcription factors, and in common with many of these, Zta possesses a conserved cysteine residue in its basic region (C189) and a further...

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Bibliographic Details
Main Authors: Schelcher, Celine, Valencia, Sarah, Delecluse, Henri-Jacques, Hicks, Matthew, Sinclair, Alison J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1262594/
https://ncbi.nlm.nih.gov/pubmed/16227304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.21.13822-13828.2005
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