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The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling

Newly spliced mRNAs in mammalian cells are characterized by a complex of proteins at exon–exon junctions. This complex recruits Upf3 and Upf2, which function in nonsense-mediated mRNA decay (NMD). Both Upf proteins are detected on mRNA bound by the major nuclear cap-binding proteins CBP80/CBP20 but...

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Udgivet i:EMBO J
Principais autores: Lejeune, Fabrice, Ishigaki, Yasuhito, Li, Xiaojie, Maquat, Lynne E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
Fag:
Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126094/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093754/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf345
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