Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain

The key enzyme in coronavirus polyprotein processing is the viral main proteinase, M(pro), a protein with extremely low sequence similarity to other viral and cellular proteinases. Here, the crystal structure of the 33.1 kDa transmissible gastroenteritis (corona)virus M(pro) is reported. The structu...

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Detalles Bibliográficos

Publicado en:	EMBO J
Principais autores:	Anand, Kanchan, Palm, Gottfried J., Mesters, Jeroen R., Siddell, Stuart G., Ziebuhr, John, Hilgenfeld, Rolf
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2002
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126080/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093723/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf327
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