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Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain
The key enzyme in coronavirus polyprotein processing is the viral main proteinase, M(pro), a protein with extremely low sequence similarity to other viral and cellular proteinases. Here, the crystal structure of the 33.1 kDa transmissible gastroenteritis (corona)virus M(pro) is reported. The structu...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2002
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126080/ https://ncbi.nlm.nih.gov/pubmed/12093723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf327 |
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