A single nonpolar residue in the deep pore of related K+ channels acts as a K+:Rb+ conductance switch.

K+ and Rb+ conductances (GK+ and GRb+) were investigated in two delayed rectifier K+ channels (Kv2.1 and Kv3.1) cloned from rat brain and a chimera (CHM) of the two channels formed by replacing the putative pore region of Kv2.1 with that of Kv3.1. CHM displayed ion conduction properties which resemb...

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Detalhes bibliográficos
Main Authors: Kirsch, G E, Drewe, J A, Taglialatela, M, Joho, R H, DeBiasi, M, Hartmann, H A, Brown, A M
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1260507/
https://ncbi.nlm.nih.gov/pubmed/1600093
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