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Electrostatic influences of charged inner pore residues on the conductance and gating of small conductance Ca(2+) activated K(+) channels

SK channels underlie important physiological functions by linking calcium signaling with neuronal excitability. Potassium currents through SK channels demonstrate inward rectification, which further reduces their small outward conductance. Although it has been generally attributed to block of outwar...

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Détails bibliographiques
Auteurs principaux: Li, Weiyan, Aldrich, Richard W.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076840/
https://ncbi.nlm.nih.gov/pubmed/21422289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103090108
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