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Quinidine interaction with Shab K(+) channels: pore block and irreversible collapse of the K(+) conductance
Quinidine is a commonly used antiarrhythmic agent and a tool to study ion channels. Here it is reported that quinidine equilibrates within seconds across the Sf9 plasma membrane, blocking the open pore of Shab channels from the intracellular side of the membrane in a voltage-dependent manner with 1:...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2956894/ https://ncbi.nlm.nih.gov/pubmed/20547671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.193128 |
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