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Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence
The cyclin-dependent kinase (CDK) inhibitor p21(Waf1/Cip1/Sdi1) was identified initially as a gene induced in senescent cells and itself has been shown to cause permanent growth arrest/senescence. Reactive oxygen species (ROS), a byproduct of oxidative processes, can also induce an irreversible grow...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125979/ https://ncbi.nlm.nih.gov/pubmed/11980715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.9.2180 |
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