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Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

Here we analyze the functional interaction between Ku86 and telomerase at the mammalian telomere by studying mice deficient for both proteins. We show that absence of Ku86 prevents the end-to-end chromosomal fusions that result from critical telomere shortening in telomerase-deficient mice. In addit...

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Udgivet i:EMBO J
Principais autores: Espejel, Silvia, Franco, Sonia, Rodríguez-Perales, Sandra, Bouffler, Simon D., Cigudosa, Juan C., Blasco, María A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125978/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11980718/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.9.2207
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