Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation

To study the role of caspase-6 during nuclear disassembly, we generated a chicken DT40 cell line in which both alleles of the caspase-6 gene were disrupted. No obvious morphological differences were observed in the apoptotic process in caspase-6- deficient cells compared with the wild type. However,...

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Библиографические подробности

Опубликовано в::	EMBO J
Главные авторы:	Ruchaud, Sandrine, Korfali, Nadia, Villa, Pascal, Kottke, Timothy J., Dingwall, Colin, Kaufmann, Scott H., Earnshaw, William C.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 2002
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125972/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11953316/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.8.1967
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