Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation

To study the role of caspase-6 during nuclear disassembly, we generated a chicken DT40 cell line in which both alleles of the caspase-6 gene were disrupted. No obvious morphological differences were observed in the apoptotic process in caspase-6- deficient cells compared with the wild type. However,...

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Bibliographic Details
Main Authors: Ruchaud, Sandrine, Korfali, Nadia, Villa, Pascal, Kottke, Timothy J., Dingwall, Colin, Kaufmann, Scott H., Earnshaw, William C.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC125972/
https://ncbi.nlm.nih.gov/pubmed/11953316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.8.1967
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