Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA

The human single-stranded DNA-binding protein, replication protein A (RPA) binds DNA in at least two different modes: initial [8–10 nucleotides (nt)] and stable (∼30 nt). Switching from 8 to 30 nt mode is associated with a large conformational change. Here we report the 2.8 Å structure of the RPA tr...

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Pubblicato in:	EMBO J
Autori principali:	Bochkareva, Elena, Korolev, Sergey, Lees-Miller, Susan P., Bochkarev, Alexey
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125950/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11927569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.7.1855
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