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Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
The human single-stranded DNA-binding protein, replication protein A (RPA) binds DNA in at least two different modes: initial [8–10 nucleotides (nt)] and stable (∼30 nt). Switching from 8 to 30 nt mode is associated with a large conformational change. Here we report the 2.8 Å structure of the RPA tr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125950/ https://ncbi.nlm.nih.gov/pubmed/11927569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.7.1855 |
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