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SR proteins and hnRNP H regulate the splicing of the HIV-1 tev-specific exon 6D

A naturally arising point mutation in the env gene of HIV-1 activates the aberrant inclusion of the cryptic exon 6D into most viral messages, leading to inefficient viral replication. We set out to understand how a single nucleotide substitution could cause such a dramatic change in splicing. We hav...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Caputi, Massimo, Zahler, Alan M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2002
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125874/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11847131/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.4.845
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