A ‘three-pronged’ binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

The SH2 domain protein SAP/SH2D1A, encoded by the X-linked lymphoproliferative (XLP) syndrome gene, associates with the hematopoietic cell surface receptor SLAM in a phosphorylation-independent manner. By screening a repertoire of synthetic peptides, the specificity of SAP/SH2D1A has been mapped and...

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Autori principali: Hwang, Peter M., Li, Chengjun, Morra, Massimo, Lillywhite, Jennifer, Muhandiram, D.Ranjith, Gertler, Frank, Terhorst, Cox, Kay, Lewis E., Pawson, Tony, Forman-Kay, Julie D., Li, Shun-Cheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2002
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC125837/
https://ncbi.nlm.nih.gov/pubmed/11823424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.3.314
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