Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP. SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors. A defining feature of XLP is exquisite sensitivity to infection with EBV, a B-lymphotropi...

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Detalhes bibliográficos
Main Authors: Palendira, Umaimainthan, Low, Carol, Chan, Anna, Hislop, Andrew D., Ho, Edwin, Phan, Tri Giang, Deenick, Elissa, Cook, Matthew C., Riminton, D. Sean, Choo, Sharon, Loh, Richard, Alvaro, Frank, Booth, Claire, Gaspar, H. Bobby, Moretta, Alessandro, Khanna, Rajiv, Rickinson, Alan B., Tangye, Stuart G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206011/
https://ncbi.nlm.nih.gov/pubmed/22069374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001187
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