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A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis

INI1 (integrase interactor 1)/hSNF5 is a component of the mammalian SWI/SNF complex and a tumor suppressor mutated in malignant rhabdoid tumors (MRT). We have identified a nuclear export signal (NES) in the highly conserved repeat 2 domain of INI1 that is unmasked upon deletion of a downstream seque...

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Udgivet i:EMBO J
Principais autores: Craig, Errol, Zhang, Zhi-Kai, Davies, Kelvin P., Kalpana, Ganjam V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125819/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782423/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.1.31
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