The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation

The negative regulator Cbl functions as a ubiquitin ligase towards activated receptor tyrosine kinases and facilitates their transport to lysosomes. Whether Cbl ubiquitin ligase activity mediates its negative regulatory effects on cytoplasmic tyrosine kinases of the Syk/ZAP-70 family has not been ad...

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Autors principals: Rao, Navin, Ghosh, Amiya K., Ota, Satoshi, Zhou, Pengcheng, Reddi, Alagarsamy Lakku, Hakezi, Kaoru, Druker, Brian K., Wu, Jiong, Band, Hamid
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2001
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC125791/
https://ncbi.nlm.nih.gov/pubmed/11742985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.24.7085
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