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Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design
Bacillus anthracis secretes three polypeptides: protective antigen (PA), lethal factor (LF), and edema factor (EF), which interact at the surface of mammalian cells to form toxic complexes. LF and EF are enzymes that target substrates within the cytosol; PA provides a heptameric pore to facilitate L...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1257733/ https://ncbi.nlm.nih.gov/pubmed/16214885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507488102 |
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