Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design

Bacillus anthracis secretes three polypeptides: protective antigen (PA), lethal factor (LF), and edema factor (EF), which interact at the surface of mammalian cells to form toxic complexes. LF and EF are enzymes that target substrates within the cytosol; PA provides a heptameric pore to facilitate L...

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Main Authors: Karginov, Vladimir A., Nestorovich, Ekaterina M., Moayeri, Mahtab, Leppla, Stephen H., Bezrukov, Sergey M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257733/
https://ncbi.nlm.nih.gov/pubmed/16214885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507488102
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