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Low mobility of phosphatidylinositol 4,5-bisphosphate underlies receptor specificity of Gq-mediated ion channel regulation in atrial myocytes

We have shown previously that cardiac G protein-gated inwardly rectifying K(+) (GIRK) channels are inhibited by Gq protein-coupled receptors (GqPCRs) via phosphatidylinositol 4,5-bisphosphate (PIP(2)) depletion in a receptor-specific manner. To investigate the mechanism of receptor specificity, we e...

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מידע ביבליוגרפי
Main Authors: Cho, Hana, Kim, Yeon A., Yoon, Jin-Young, Lee, Doyun, Kim, Jae Ho, Lee, Suk Ho, Ho, Won-Kyung
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2005
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257688/
https://ncbi.nlm.nih.gov/pubmed/16217031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408851102
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