Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4(+) T lymphocytes

DC-specific ICAM3-grabbing non-integrin (DC-SIGN), which is expressed on DCs, can interact with a variety of pathogens such as HIV-1, hepatitis C, Ebola, cytomegalovirus, Dengue virus, Mycobacterium, Leishmania, and Candida albicans. We demonstrate that human milk can inhibit the DC-SIGN–mediated tr...

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Bibliographic Details
Main Authors: Naarding, Marloes A., Ludwig, Irene S., Groot, Fedde, Berkhout, Ben, Geijtenbeek, Teunis B.H., Pollakis, Georgios, Paxton, William A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257537/
https://ncbi.nlm.nih.gov/pubmed/16239964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25105
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