Binding of Human Milk to Pathogen Receptor DC-SIGN Varies with Bile Salt-Stimulated Lipase (BSSL) Gene Polymorphism

OBJECTIVE: Dendritic cells bind an array of antigens and DC-SIGN has been postulated to act as a receptor for mucosal pathogen transmission. Bile salt-stimulated lipase (BSSL) from human milk potently binds DC-SIGN and blocks DC-SIGN mediated trans-infection of CD4(+) T-lymphocytes with HIV-1. Objec...

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Autors principals: Stax, Martijn J., Naarding, Marloes A., Tanck, Michael W. T., Lindquist, Susanne, Hernell, Olle, Lyle, Robert, Brandtzaeg, Per, Eggesbø, Merete, Pollakis, Georgios, Paxton, William A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046167/
https://ncbi.nlm.nih.gov/pubmed/21386960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017316
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