HIV-1 Disease Progression Is Associated with Bile-Salt Stimulated Lipase (BSSL) Gene Polymorphism

BACKGROUND: DC-SIGN expressed by dendritic cells captures HIV-1 resulting in trans-infection of CD4(+) T-lymphocytes. However, BSSL (bile-salt stimulated lipase) binding to DC-SIGN interferes with HIV-1 capture. DC-SIGN binding properties of BSSL associate with the polymorphic repeated motif of BSSL...

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Autores principales: Stax, Martijn J., Kootstra, Neeltje A., van 't Wout, Angélique B., Tanck, Michael W. T., Bakker, Margreet, Pollakis, Georgios, Paxton, William A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295759/
https://ncbi.nlm.nih.gov/pubmed/22412885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032534
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