Hepatitis C Virus Targets DC-SIGN and L-SIGN To Escape Lysosomal Degradation

Hepatitis C virus (HCV) is a major health problem. However, the mechanism of hepatocyte infection is largely unknown. We demonstrate that the dendritic cell (DC)-specific C-type lectin DC-SIGN and its liver-expressed homologue L-SIGN/DC-SIGNR are important receptors for HCV envelope glycoproteins E1...

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Detalhes bibliográficos
Main Authors: Ludwig, Irene S., Lekkerkerker, Annemarie N., Depla, Erik, Bosman, Fons, Musters, René J. P., Depraetere, Stany, van Kooyk, Yvette, Geijtenbeek, Teunis B. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC446128/
https://ncbi.nlm.nih.gov/pubmed/15254204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.15.8322-8332.2004
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