Unique misinsertion specificity of polι may decrease the mutagenic potential of deaminated cytosines
DNA polymerase ι (polι) is a distributive error-prone enzyme that can incorporate nucleotides opposite a variety of DNA lesions. Further elongation is, however, either substantially inhibited or completely abolished. Here, we provide evidence that polι can facilitate the efficient bypass of uracil a...
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| Publicat a: | EMBO J |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125734/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707422/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.22.6520 |
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