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Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

Werner syndrome (WS) is a human premature aging disorder characterized by chromosomal instability. The cellular defects of WS presumably reflect compromised or aberrant function of a DNA metabolic pathway that under normal circumstances confers stability to the genome. We report a novel interaction...

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Udgivet i:EMBO J
Principais autores: Brosh, Robert M., von Kobbe, Cayetano, Sommers, Joshua A., Karmakar, Parimal, Opresko, Patricia L., Piotrowski, Jason, Dianova, Irina, Dianov, Grigory L., Bohr, Vilhelm A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125684/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11598021/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.20.5791
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