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Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

Yeast Rad52 DNA-repair mutants exhibit pronounced radiation sensitivity and a defect in homologous re combination (HR), whereas vertebrate cells lacking Rad52 exhibit a nearly normal phenotype. Bio chemical studies show that both yeast Rad52 and Rad55–57 (Rad51 paralogs) stimulate DNA-strand exchang...

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Udgivet i:EMBO J
Principais autores: Fujimori, Akira, Tachiiri, Seiji, Sonoda, Eiichiro, Thompson, Larry H., Dhar, Pawan Kumar, Hiraoka, Masahiro, Takeda, Shunichi, Zhang, Yong, Reth, Michael, Takata, Minoru
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125654/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11574483/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.19.5513
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