Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

Yeast Rad52 DNA-repair mutants exhibit pronounced radiation sensitivity and a defect in homologous re combination (HR), whereas vertebrate cells lacking Rad52 exhibit a nearly normal phenotype. Bio chemical studies show that both yeast Rad52 and Rad55–57 (Rad51 paralogs) stimulate DNA-strand exchang...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	EMBO J
Hauptverfasser:	Fujimori, Akira, Tachiiri, Seiji, Sonoda, Eiichiro, Thompson, Larry H., Dhar, Pawan Kumar, Hiraoka, Masahiro, Takeda, Shunichi, Zhang, Yong, Reth, Michael, Takata, Minoru
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125654/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11574483/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.19.5513
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!