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Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
Oxygen-dependent proteolytic destruction of hypoxia-inducible factor-α (HIF-α) subunits plays a central role in regulating transcriptional responses to hypoxia. Recent studies have defined a key function for the von Hippel–Lindau tumour suppressor E3 ubiquitin ligase (VHLE3) in this process, and hav...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125617/ https://ncbi.nlm.nih.gov/pubmed/11566883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.18.5197 |
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