Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

Aberrant activation of β-catenin contributes to the onset of a variety of tumors. We report that a tumor-derived β-catenin mutant induces accumulation and activation of the p53 tumor suppressor protein. Induction is mediated through ARF, an alternative reading frame product of the INK4A tumor suppre...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Damalas, Alexander, Kahan, Sharon, Shtutman, Michael, Ben-Ze’ev, Avri, Oren, Moshe
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125598/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11532955/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.17.4912
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