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Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation
Aberrant activation of β-catenin contributes to the onset of a variety of tumors. We report that a tumor-derived β-catenin mutant induces accumulation and activation of the p53 tumor suppressor protein. Induction is mediated through ARF, an alternative reading frame product of the INK4A tumor suppre...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125598/ https://ncbi.nlm.nih.gov/pubmed/11532955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.17.4912 |
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