Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation
Aberrant activation of β-catenin contributes to the onset of a variety of tumors. We report that a tumor-derived β-catenin mutant induces accumulation and activation of the p53 tumor suppressor protein. Induction is mediated through ARF, an alternative reading frame product of the INK4A tumor suppre...
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| Vydáno v: | EMBO J |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2001
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125598/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11532955/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.17.4912 |
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