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The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
PKB/Akt, S6K1 and SGK are related protein kinases activated in a PI 3-kinase-dependent manner in response to insulin/growth factors signalling. Activ ation entails phosphorylation of these kinases at two residues, the T-loop and the hydrophobic motif. PDK1 activates S6K, SGK and PKB isoforms by phos...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125563/ https://ncbi.nlm.nih.gov/pubmed/11500365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.16.4380 |
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