Rsk2 allosterically activates estrogen receptor α by docking to the hormone-binding domain

We describe a novel mechanism for transcriptional regulation, in which docking of p90 ribosomal S6 kinase 2 (Rsk2) to the hormone-binding domain (HBD) of estrogen receptor α (ERα) induces a conformational change that enhances the transcriptional activation function contained in the HBD. A constituti...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Clark, David E., Poteet-Smith, Celeste E., Smith, Jeffrey A., Lannigan, Deborah A.
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2001
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125527/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11432835/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.13.3484
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