Rsk2 allosterically activates estrogen receptor α by docking to the hormone-binding domain
We describe a novel mechanism for transcriptional regulation, in which docking of p90 ribosomal S6 kinase 2 (Rsk2) to the hormone-binding domain (HBD) of estrogen receptor α (ERα) induces a conformational change that enhances the transcriptional activation function contained in the HBD. A constituti...
שמור ב:
| הוצא לאור ב: | EMBO J |
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| Principais autores: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group
2001
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125527/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11432835/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.13.3484 |
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