Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis

C3G is a guanine nucleotide exchange factor (GEF) for Rap1, and is activated via Crk adaptor protein. To understand the physiological role of C3G, we generated C3G knockout mice. C3G(–)(/–) homozygous mice died before embryonic day 7.5. The lethality was rescued by the expression of the human C3G tr...

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Pubblicato in:	EMBO J
Autori principali:	Ohba, Yusuke, Ikuta, Koichi, Ogura, Atsuo, Matsuda, Junichiro, Mochizuki, Naoki, Nagashima, Kazuo, Kurokawa, Kazuo, Mayer, Bruce J., Maki, Kazushige, Miyazaki, Jun-ichi, Matsuda, Michiyuki
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125518/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11432821/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.13.3333
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