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Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis
C3G is a guanine nucleotide exchange factor (GEF) for Rap1, and is activated via Crk adaptor protein. To understand the physiological role of C3G, we generated C3G knockout mice. C3G(–)(/–) homozygous mice died before embryonic day 7.5. The lethality was rescued by the expression of the human C3G tr...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125518/ https://ncbi.nlm.nih.gov/pubmed/11432821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.13.3333 |
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