Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis
C3G is a guanine nucleotide exchange factor (GEF) for Rap1, and is activated via Crk adaptor protein. To understand the physiological role of C3G, we generated C3G knockout mice. C3G(–)(/–) homozygous mice died before embryonic day 7.5. The lethality was rescued by the expression of the human C3G tr...
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| Vydáno v: | EMBO J |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2001
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125518/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11432821/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.13.3333 |
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