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Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme
The 5′ capping of mammalian pre-mRNAs is initiated by RNA triphosphatase, a member of the cysteine phosphatase superfamily. Here we report the 1.65 Å crystal structure of mouse RNA triphosphatase, which reveals a deep, positively charged active site pocket that can fit a 5′ triphosphate end. Structu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125469/ https://ncbi.nlm.nih.gov/pubmed/11350947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.10.2575 |
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