Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme

The 5′ capping of mammalian pre-mRNAs is initiated by RNA triphosphatase, a member of the cysteine phosphatase superfamily. Here we report the 1.65 Å crystal structure of mouse RNA triphosphatase, which reveals a deep, positively charged active site pocket that can fit a 5′ triphosphate end. Structu...

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Detalles Bibliográficos

Publicado en:	EMBO J
Autores principales:	Changela, Anita, Ho, C.Kiong, Martins, Alexandra, Shuman, Stewart, Mondragón, Alfonso
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 2001
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125469/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11350947/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.10.2575
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