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Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
The Raf kinases play a key role in relaying signals elicited by mitogens or oncogenes. Here, we report that c-raf-1(–/–) embryos are growth retarded and die at midgestation with anomalies in the placenta and in the fetal liver. Although hepatoblast proliferation does not appear to be impaired, c-raf...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125416/ https://ncbi.nlm.nih.gov/pubmed/11296228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.8.1952 |
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