Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols

Endonuclease III, encoded by nth in Escherichia coli, removes thymine glycols (Tg), a toxic oxidative DNA lesion. To determine the biological significance of this repair in mammals, we established a mouse model with mutated mNth1, a homolog of nth, by gene targeting. The homozygous mNth1 mutant mice...

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發表在:	EMBO J
Principais autores:	Takao, Masashi, Kanno, Shin-ichiro, Shiromoto, Tatsuya, Hasegawa, Rei, Ide, Hiroshi, Ikeda, Shogo, Sarker, Altraf H., Seki, Shuji, Xing, James Z., Le, X.Chris, Weinfeld, Michael, Kobayashi, Kumiko, Miyazaki, Jun-ichi, Muijtjens, Manja, Hoeijmakers, Jan H.J., van der Horst, Gijsbertus, Yasui, Akira
格式:	Artigo
語言:	Inglês
出版:	Nature Publishing Group 2002
主題:	Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125395/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093749/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf350
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